Vasodilator Therapy in Acute Hemorrhagic Shock

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Vasodilator Therapy in Acute Hemorrhagic Shock.

• Irreversible shock associated with acute blood loss is a serious clinical problem.' Attempts have been made to treat this form of shock with a variety of therapeutic agents including vasopressor drugs, steroids, and plasma expanders. Most popular has been the employment of the vasopressor agents, levarterenol (Levophed) and metaraminol (Aramine), which support blood pressure mainly through an...

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Vasodilator Therapy in Acute Myocardial Infarction

Twenty-six patients with complicated acute myocardial infarction were studied in order to compare the hemodynamic effects of sodium nitroprusside (NP) and nitroglycerin (GTN). All patients received NP and 18 of the 26 also received GTN to evaluate both drugs in the same individuals. Both agents produced significant declines in mean arterial pressure, total peripheral resistance (TPR), and heart...

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Reduction of hemorrhagic shock–induced acute kidney injury by lower limb ischemic preconditioning in rats

Introduction: During hemorrhagic shock (HS), the kidneys are one of the primary target organs involved. Oxidative stress is shown to be enhanced in different models of acute kidney injury (AKI). Remote ischemic preconditioning (RPC) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. In this study, we investigated the effects of brief hind l...

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Rat hepatic and splanchnic vascular responses to anaphylactic shock, compared with hemorrhagic or vasodilator-induced shock.

BACKGROUND Hemodynamics during anaphylactic shock remain unclear. We determined hepatic and splanchnic responses to anaphylactic hypotension, compared with hemorrhage or sodium nitroprusside (SNP)-induced hypotension, in anesthetized rats. MATERIALS AND METHODS Portal pressure, systemic arterial pressure (SAP), central venous pressure, portal and hepatic arterial blood flow were measured. Spl...

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Vasodilator therapy in acute myocardial infarction.

In the context of these studies, the evidence indicates that cardiac performance can improve significantly during vasodilator therapy in acute MI complicated by pump failure. Although the clinical course in uncomplicated patients is good, even without active therapeutic interventions, prognosis in patients with pump failure treated by standard methods (digitalis and diutetics) is discouraging. ...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1965

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.16.1.58